New NMN Treatment for COVID-19

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Summary

Who I am

I hope you find this information useful, feel free to share this as you would like, it is not copyrighted in any way. To confirm the facts in this article I exchanged emails with Dr. Huizenga and did a phone interview with another of the involved parties. To better withstand scrutiny I limited the information shared here to just what is in the scientific papers, some non-essential facts and definitions from Wikipedia, and the email exchange with Dr Huizenga where he confirmed details of the prescribed treatment. I also found a story in the main stream media with nearly identical facts here.

TZNMN

Dr. Huizenga

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The Patient

The next day, 8 days after she first felt symptoms, she was prescribed Zithromax, Hydroxychloroquine and Zinc Sulfate. Zithromax is an anti-bacterial drug which is used to prevent bacterial infections that often occur as patients struggle to fight off viruses. Hydroxychloroquine is a drug that is widely used to treat malaria and has been used with mixed success against COVID-19. Zinc Sulfate, as was discussed earlier, is an essential element found normally in one’s diet and is added in to help the Hydroxychloroquine fight the virus. Three days later she was much worse. Her saturated oxygen had dropped down close to 90% which is a clinical threshold for hypoxemia which means low oxygen. Her fever had risen to 103 F and a new chest x-ray clearly showed infection in both of her lungs. She was admitted to the Cedars-Sinai Medical Center hospital where blood tests highlighted her deteriorating condition.

According to Dr. H, her C-reactive protein was “astronomically elevated”. C-reactive protein is found in the blood and rises during inflammation which is part of the body’s natural response to infections. A normal C-reactive protein level is between 0.8–3.0 mg/L. Her C-reactive protein was 217 mg/L, or 72 times higher than the maximum normal reading. Other blood markers showed similar signs of distress. Two days later she felt “she was unable to breathe” and a new chest x-ray showed even more infection in her lungs. Dr. H, though, was not flying blind and in his paper describing this case he included statistics from a Chinese study where they measured the C-reactive protein levels of 150 hospitalized patients with confirmed COVID-19. Of the 150 patients only 82 survived and those survivors had an average C-reactive protein measurement of 35 mg/L and a max of 125 mg/L. Put another way, no one in the study survived who had a C-reactive protein level greater than 125 mg/L. Dr. H’s patient had a C-reactive Protein level of 217 mg/L, almost twice the lethal level in the Chinese study. In Dr. H’s own words, the blood tests “strongly predicted a fatal outcome.” In other words, she was dying.

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Boston

The paper Amber was working on would be titled “Why does COVID-19 disproportionately affect the elderly?” It deals with the question of what happens inside the bodies of older people and why they die at a greater rate. In the paper the authors write that “over 80% of hospitalizations (for COVID-19) are those over 65 years of age with a greater than 23-fold greater risk of death.” This isn’t news, doctors know from their experiences that the old are at much greater risk of dying from COVID-19. Amber and her co-authors wanted to know why.

The paper starts by going into great detail describing how COVID-19 affects a typical older person. The virus typically enters the nose, mouth or eyes and binds to human epithelial cells that form the surface layer of tissues and organs in the body. The virus often spreads from the back of the nose to the throat and lungs which can, according to the paper “result in widespread endothelial dysfunction in the lung, heart, kidney, liver and brain.” The authors continue, “Even if viral loads decline, a type of cytokine release syndrome can rapidly develop”. Cytokines are powerful chemicals released by the human immune system when it attacks a virus. The researchers go on to explain how these cytokines not only attack the virus, they can directly attack the body itself. This self inflicted wounding of the body can be “characterized by disseminated intravascular coagulation (body wide blood clots), . . . liver damage, renal dysfunction (partial kidney failure), cardiovascular inflammation (inflammation of the heart and blood vessels), coagulopathy (excessive bleeding) and death.” When this happens researchers call it a “cytokine storm”.

The Decision

Back in Boston, Amber L Mueller, PhD. and the team at Sinclair Lab were furiously working to answer the same question, though not for one patient, for the whole world. Their paper would go into amazing detail describing the varied chemical pathways and cellular interactions that occur as the human immune system battles the COVID-19 virus. This was not the point though. They would go much further. The Sinclair Lab is world renowned for researching how different combinations of drugs and supplements can increase longevity and reverse certain diseases. Amber and her co-authors would recommend compounds that could potentially stop the cytokine storm. They would read through and reference a total of 150 other scientific papers that among other things, identified a depletion or lack of NAD+ (Nicotinamide Adenine Dinucleotide) as a key factor in cytokine storms. NAD+ is found in all living cells and your body naturally creates and attempts to maintain an optimal level of NAD+ inside each of your cells, though this does not always work.

According to the authors “During aging, NAD+ levels decline . . . (and) this decline, exacerbated by COVID-19, might therefore promote hyperactivation of NLRP3 (a protein coding gene) and . . . trigger cytokine storms in COVID-19 patients”. According to their theories, certain compounds could help boost NAD+ and potentially halt cytokine storms. They would write, “Given the increasing evidence that lower NAD+ levels in the lung and vascular endothelium contribute to poor COVID-19 outcomes, NAD boosters . . .such as NMN (Nicotinamide Mono-Nucleotide) and NR (Nicotinamide Riboside) have been suggested as first-line treatments against COVID-19, especially (in) aged patients.”

This was the clear scientific reasoning that other researchers would need to set up clinical trials and the critical advice that front line doctors would need to evaluate new treatments for their most serious COVID-19 cases. The world needed this information now. Normally scientists preparing a paper submit it to an academic journal where other scientists review it for errors before it is published. This is called peer review, and it helps make science more factual and accurate. It also takes alot of time that the world in the middle of a pandemic does not have. Like many scientists, Amber and her co-authors would skip this peer review process and release the paper online. The only problem for Dr. H was that even so, the paper Amber was working on would not be released until April 30th 2020.

Dr. H had a critical decision to make. Should he wait for his patient to decline further and hope she could recover in the intensive care unit or was there something he could do for her right now? Dr. H decided not to wait. On March 26th he prescribed Tri-methyl-glycine, NMN, Zinc Sulfate and Salt, all four components of TZNMN. He may well have been the first doctor to use this combination treatment on a COVID-19 patient. How did he know to do this? We don’t know this from his paper and above all, none of that mattered for his patient. All that mattered to her was would TZNMN work. Could it boost her NAD+ and would this stop the cytokine storm?

The following is Dr. H’s prescription from the case study and confirmed by email from him:

“Betaine 0.835 grams BID” (taken mixed into water 2 times per day)

“Zinc 220 mg PO QD” (taken orally 1 time per day)

“NMN 1.67 grams BID” (taken mixed into water 2 times per day)

“Na Cl 50 mg BID” (taken mixed into water 2 times per day)

Dr Huizenga added 835 mg of Trimethylglycine powder (TMG) (as Betaine Anhydrous), 1.67 g of NMN powder (Nicotinamide Mono-Nucleotide) and 50 mg of Salt (Sodium Chloride — Na Cl) to 400 cc of water which she would drink on an empty stomach two times per day, once in the morning and once in the evening. One time per day she would also swallow one 220mg Zinc Sulfate capsule which yields 50mg of elemental zinc.

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The Outcome

At the end of her 12 day TZNMN treatment she had no negative symptoms, had tested negative for the COVID-19 virus and her breathing and saturated oxygen levels were normal. Dr. H wrote that since then he has treated two other elderly patients with what I call TZNMN. They had confirmed COVID-19 and were suffering from fever, chest pressure, cough, headaches and low energy. The two patients both took the TZNMN “cocktail” at home and within 36 to 48 hours they both reported improvements in their symptoms.

Safety

I coined the term “TZNMN” to give everyone a more accurate way to talk about this new COVID-19 treatment. I want to recognize the following people as co-inventors of TZNMN and thank them for their contributions. First Dr. Robert Huizenga for successfully trying out this new treatment on his near fatal patient and anyone else who helped him come up with the detailed protocol. Secondly Amber L Mueller, PhD., Meave S. McNamara, and lab founder David Sinclair, PhD for describing and illustrating the complex biological chemistry involved in how the body’s immune system can be affected by COVID-19. In their paper the Sinclair Lab authors recommended NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) to help boost NAD+ in COVID-19 patients at nearly the same time as Dr. H was prescribing NMN for his first patient.

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Doctor H’s Protocol in “Doctor Speak”

“Betaine 0.835 grams BID” (Starting evening of day 1 thru day 12 taken mixed in 400 cc of water 2 times per day)

“Zinc Sulfate 220 PO QD” (Starting evening of day 1 thru day 12. “Zinc Sulfate-220” is 220 mg of Zinc Sulfate yielding 50 mg of pure elemental Zinc, taken orally 1 time per day)

“NMN 1.67 grams BID” (Starting evening of day 1 thru day 6 taken mixed in 400 cc water 2 times per day)

“NMN 1.50 grams BID” (Days 7–12 taken mixed in 400 cc water 2 times per day)

“Na 50 mg BID” (Starting evening of day 1 thru day 12 Table Salt taken mixed into 400 cc water 2 times per day)

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Dr. H’s Protocol written out in common English

TMG = Trimethylglycine powder (as Betaine Anhydrous) (A total of 20g of TMG powder required for complete 12 day treatment)

ZN = Zinc Sulfate 220 mg tablet, each tablet yields 50 mg pure elemental zinc (A total 12 tablets of Zinc Sulfate 220 mg required for complete 12 day treatment)

NMN = Nicotinamide Mono-Nucleotide powder (A total 36.4 grams of NMN required for complete 12 day treatment. Note 30 grams of NMN gives slightly shortened 10 day treatment)

Salt = Regular Table Salt or Sodium Chloride (Na Cl) (A total of 1.2 grams Salt required for 12 day complete treatment)

Day 1–6 (Take on an empty stomach 1 hour before eating food, start evening on day 1)

6 AM —Mix into 400 cc of water, 835 mg TMG, 1,670 mg NMN, 50 mg of Salt, drink slowly over a few minutes and swallow one ZN 220 mg tablet

6 PM — Mix into 400 cc of water, 835 mg TMG, 1,670 mg NMN, 50 mg of Salt, drink slowly over a few minutes

Day 7–12 (Take on an empty stomach 1 hour before eating food)

6 AM —Mix into 400 cc of water, 750 mg TMG, 1,500 mg NMN, 50 mg of Salt, drink slowly over a few minutes and swallow one ZN 220 mg tablet

6 PM — Mix into 400 cc of water, 750 mg TMG, 1,500 mg NMN, 50 mg of Salt, drink slowly over a few minutes

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Access

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3581388

Peer reviewed paper by Amber L Mueller, PhD, Meave S. McNamara, David Sinclair, PhD, preprints.org > doi: 10.20944/preprints202004.0548.v1 “Why Does COVID-19 Disproportionately Affect the Elderly?”

https://www.aging-us.com/article/103344

Paper by Qiurong Ruan, Kun Yang, Wenxia Wang, Lingyu Jiang, and Jianxin Song, Intensive Care Med. 2020 Mar 3 : 1–3. “Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080116/

Conflict of Interest

I certify that I have no affiliations or involvement in any organization or entity with any material financial or non-financial interest in the subject matter or materials discussed in this manuscript.

This story is not copyrighted in any way.

Wesley R. Lapp, B.A.E. May 15th, 2020

I am dad, professional Aerospace engineer and amateur longevity enthusiast. I also like to freedive and wingfoil.